Contraindications
Hyperosmolar states, HTN, oedema.
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Special Precautions
Hypocalcaemia, hypoventilatory states, alkalosis. Renal disease. Childn including neonates. Pregnancy and lactation.
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Adverse Reactions
Mild diuresis, stomach cramps, flatulence, diarrhoea, GI ulceration, hypokalaemia, metabolic alkalosis, tiredness, dyspnoea, anxiety, mood swings.
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Drug Interactions
Enhances elimination of salicylates and barbiturates. May increase the half-life of quinidine, ephedrine, pseudoephedrine. Additive effect w/ Na retention caused by corticosteroids. Potentiates renal excretion of tetracycline. Hypochloraemic alkalosis may occur w/ concomitant K-depleting diuretics.
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